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Johns Hopkins Team Develops Therapeutic, Nasally-Delivered DNA Vaccine for Tuberculosis

Johns Hopkins Team Develops Therapeutic, Nasally-Delivered DNA Vaccine for Tuberculosis

A team of researchers at Johns Hopkins Medicine is developing a nose-delivered inoculation against tuberculosis, the world’s leading cause of death from infectious disease. The approach fuses two tuberculosis genes to direct the immune system to fight drug-tolerant bacterial survivors. The vaccine was tested in mice and primates, showing promise for reducing TB treatment regimens and improving outcomes. Studies indicate the vaccine helped infected mice clear the disease bacteria faster and generated long-lasting localized T-cell immunity. This breakthrough vaccine may soon be used alongside first-line TB drug therapy to combat drug-resistant TB strains.
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